Is Aricept used for prevention of alzheimers as well as treatment?
Query by kevin.morehouse: Is Aricept employed for prevention of alzheimers as effectively as therapy?
Can Aricept be utilised as a preventative measure against Alzheimers or is it only employed for treatment of an current situation.
Answer by Dis Gruntled
Aricept is brand name for the drug donepezil.
At the moment, there is no definitive proof that use of donepezil or other similar agents alters the course or progression of Alzheimer’s disease. However, 6-12 month controlled scientific studies have shown modest positive aspects in cognition and/or behavior, such as one published in 1999. Pilot studies have reported that donepezil treatment could potentially have effects on markers of condition progression, such as hippocampal volume. As a result, a lot of neurologists, psychiatrists, and major care physicians use donepezil in patients with Alzheimer’s disease. In 2005, the UK National Institute for Clinical Excellence (Great) withdrew its recommendation for use of the drug for mild-to-moderate AD, on the basis that there is no considerable improvement in functional outcome of top quality of life or of behavioral signs and symptoms. Nonetheless, Good revised its suggestions to propose that donepezil be employed in moderate stage individuals for whom the proof is strongest.
Whilst the drug is at the moment indicated for mild to moderate Alzheimer’s, there is also evidence from two trials that it may possibly be efficient for moderate to extreme condition. An instance of this is a Karolinska Institute paper published in The Lancet in early 2006, which states that donepezil improves cognitive function even in individuals with extreme Alzheimer’s disease signs and symptoms.
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